I can give some insight about 2B03. I found these courses very interesting, the profs were great (just took them last year). I had Dr. Nodwell for 2B03 (unforutantly he moved to U of T), however I have heard great things about the other prof who teaches this course.
I would say the course isn't very difficult, there were two midterms and a non cumulative exam. As long as you study a few days before you can do fine on these. A big portion of the course is a 20% group presentation on an assigned paper, in which you spend all semester working on. They add a fun twist by giving a bonus 5% to the best presentation for each paper.
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Alex
Honours Biochemistry (3rd year)
McMaster University
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