Pretty much what everyone else has said. Monday to Friday during the day it's a restaurant/bar. The food has gotten better over the past couple of years, and it's decent for campus food. Don't go in there expecting superb, real restaurant quality food, it's a student pub.
Thursday and Saturday nights are club nights from 9pm to 2am. Thursday's have been phenomenal this past year with every night reaching capacity. Saturdays have been hit and miss. In addition to these regular nights, there are also special themed club nights every month or so. I think that the club nights are amazing for a student club. HUGE sound, sweet light show, typical club music, and rammed with people. If it's your type of scene, Thursday nights at 1280 are definitely for you.
1280 is also used as a concert venue. We've hosted Marianas Trench, Classified, Down With Webster, The Arkelles, and a bunch of other artists. It is also used for other events such as improv and comedy groups, and non-musical acts such as hypnotists.
Also musically-related, there are usually acoustic nights held weekly with some known acts within the genre. (I'm clueless as to who these people are, but quite a few people do come out for these nights).
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