Hey so I'm going into 3rd year Honours Life Sci -- but I'm actually switching into H. Psychology, Neuroscience and Behaviour. So I am the perfect example of how even if you DONT get into your second year program that you want, or you just didn't know what you wanted to do after 1st year (like me), you can STILL shadow your ideal program and switch into it for your third year.
The typical cutoff for getting INTO McMaster's Life Sci Program is between 87-90%..usually it is at the higher end of that (my year the cutoff was an 89). The first year is more general obviously...alot of people do struggle making that transition from HS to a University setting and because of the number of people in your classes, etc, you can expect your marks to drop 10-15%..THAT BEING SAID that doesn't ALWAYS happen (I know people who kept a 10+ average) and SECOND YEAR is wayyyyy easier in my opinion... my average skyrocketed. The minimum for all second year programs is a 6 average (VERY EASY TO OBTAIN). Yes, some programs have higher admission levels but most of them are still obtainable and are ENTIRELY DEPENDENT on the amount of people who apply to the program in that given year. For instance, PNB is a relatively small program and admission average is typically around a 7.1-7.5 (around a 75% average). With origins specializations there are even fewer positions available typically.. so you want to make sure to keep your average above a 9/10 I'd say and you should be good for most programs.
Personally I really like the set up of the program because it gives you a chance to explore your options in first year and then second year is easier because you get to take classes you are actually interested in and obviously if you like the course, you are going to do well in it. I think it is awesome that you are so interested in your future and I really do hope you choose Mac because it is amazing
I also want to stress that yeah, everyone is comparable coming into University with excellent marks and are going to be competing for some of the same things.... but the thing that makes you stand out, that gives you the upper edge is NOT your marks.. it is involvement in the school itself. So no matter where you choose, GET INVOLVED because that is going to look so much better on a resume than just a few letters on a transcript... obviously marks DO matter, but if you are applying for a summer job working with a professor in a biochem lab for instance (or any internship/related experience job) ... and everyone applying has a 9+ average? They are most likely going to choose the student not with the highest marks but someone who has been able to both get decent grades AND at the same time be super involved in their school and the surrounding Hamilton community.