I can't say anything about res, but YES! you can definitely make friends even in your second year.
I can speak from experience when I say that I spent my first year commuting, and would only go to class and then go home.. leaving no time to socialize and meet people. But even in second year, I met lots of people from tutorials, and different clubs (so definitely, try to get involved), and some of them are now my really good friends.
Don't lose hope, but do look for opportunities to get involved! Clubfest is somewhere you can start.