like particle said, it will negatively affect your admissions into professional schools (ie med school if that's where you're headed). most med schools want to see a full course load every year (meaning 5 courses per semester). Also, you won't get the certain "bonuses" that some med schools have. For example, UoT won't look at the lowest two marks you get for each year, ONLY if you have a full course load per year
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